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Multicenter Study
, 150 (3), 291-4

Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics

Multicenter Study

Prospective Study of Infantile Hemangiomas: Demographic, Prenatal, and Perinatal Characteristics

Hemangioma Investigator Group et al. J Pediatr.

Abstract

Objectives: To characterize demographic, prenatal, and perinatal features of patients with infantile hemangiomas and to determine the importance of these factors in predicting rates of complication and treatment.

Study design: We conducted a prospective study at 7 U.S. pediatric dermatology clinics. A consecutive sample of 1058 children, aged 12 years and younger, with infantile hemangiomas was enrolled between September 2002 and October 2003. A standardized questionnaire was used to collect demographic, prenatal, perinatal, and hemangioma-specific data. National Vital Statistic System Data (NVSS) was used to compare demographic variables and relevant rates of prenatal events.

Results: In comparison with the 2002 United States National Vital Statistics System birth data, we found that infants with hemangiomas were more likely to be female, white non-Hispanic, premature (P < .0001) and the product of a multiple gestation (10.6% versus 3.1%; P < .001). Maternal age was significantly higher (P < .0001), and placenta previa (3.1%) and pre-eclampsia (11.8%) were more common.

Conclusions: Infants with hemangiomas are more likely to be female, white non-Hispanic, premature, and products of multiple gestations. Prenatal associations include older maternal age, placenta previa, and pre-eclampsia. No demographic, prenatal, and perinatal factors predicted higher rates of complications or need for treatment.

Comment in

  • [Drugs News]
    C Lengellé et al. Arch Pediatr 22 (11), 1200-6. PMID 26385645.

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