Two new dfr genes in trimethoprim-resistant integron-negative Escherichia coli isolates

Antimicrob Agents Chemother. 2007 May;51(5):1863-4. doi: 10.1128/AAC.01273-06. Epub 2007 Feb 16.


Two Escherichia coli isolates resistant to trimethoprim but negative for integrons carried two new resistance genes, dfrA24 and dfrA26, remotely similar to one another and to the cassette-independent genes dfrA8 and dfrA9. The dfrA24 gene was not associated with known mobile elements, while dfrA26 was associated with the CR1 common region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Resistance, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Genes, Bacterial*
  • Integrons*
  • Microbial Sensitivity Tests
  • Polymerase Chain Reaction
  • Trimethoprim Resistance / genetics*