An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer

Cancer Res. 2007 Feb 15;67(4):1407-10. doi: 10.1158/0008-5472.CAN-06-2149.


Nitric oxide (NO) is a free radical that is involved in carcinogenesis. Recent literature indicates that endothelial NO synthase (eNOS) can modulate cancer-related events (angiogenesis, apoptosis, cell cycle, invasion, and metastasis). We review the literature linking eNOS to carcinogenesis to encourage future research assessing the role of eNOS in cancer prevention and treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Movement / physiology
  • Humans
  • Inflammation / enzymology*
  • Inflammation / pathology
  • Neoplasm Invasiveness
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Neovascularization, Pathologic / enzymology
  • Neovascularization, Pathologic / pathology
  • Nitric Oxide Synthase Type III / metabolism*


  • Nitric Oxide Synthase Type III