Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery

Pituitary. 2007;10(1):87-93. doi: 10.1007/s11102-007-0006-1.


Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Cesarean Section, Repeat
  • Deamino Arginine Vasopressin / therapeutic use
  • Diabetes Insipidus* / diagnosis
  • Diabetes Insipidus* / drug therapy
  • Diabetes Insipidus* / physiopathology
  • Diabetes, Gestational* / diagnosis
  • Diabetes, Gestational* / drug therapy
  • Diabetes, Gestational* / physiopathology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Pregnancy


  • Deamino Arginine Vasopressin