Evaluation of plasma skin regeneration technology in low-energy full-facial rejuvenation

Arch Dermatol. 2007 Feb;143(2):168-74. doi: 10.1001/archderm.143.2.168.


Objective: To evaluate the use of multiple, low-energy, full-face plasma skin regeneration treatments.

Design: Plasma skin regeneration delivers energy to the skin through plasma pulses induced by passing radiofrequency into nitrogen gas. Single-treatment, high-energy, 1-pass treatments have been demonstrated to achieve good results with an excellent safety profile. Eight volunteers underwent full-face treatments every 3 weeks, for a total of 3 treatments, using energy settings of 1.2 to 1.8 J. Before each subsequent treatment, the quality of regenerated epidermis, the degree of downtime, and erythema were recorded. Full-thickness skin biopsy specimens were obtained from 6 patients before treatment and 90 days following the last treatment. Patients were seen for follow-up 4 days after each treatment and 30 and 90 days after the third treatment.

Results: Three months after treatment, investigators found a 37% reduction in facial rhytids and study participants noted a 68% improvement in overall facial appearance. Reepithelialization was complete in 4 days. Patients assessed erythema to persist an average of 6 days after treatment. Epidermal regeneration from the first treatment was longer than from the following treatments (9 vs 4 and 5 days, respectively). One patient developed localized hyperpigmentation after the first treatment, which resolved by follow-up at day 30. No scarring or hypopigmentation occurred. A histologic evaluation 3 months after treatment revealed a band of new collagen at the dermoepidermal junction with less dense elastin in the upper dermis. The mean depth of new collagen was 72.3 mum.

Conclusions: Plasma skin regeneration using the multiple low-energy treatment technique allows significant successful treatment of photodamaged facial skin with minimal downtime. Results are comparable to a single high-energy treatment, but with less healing time.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Equipment Design
  • Face
  • Female
  • Follow-Up Studies
  • Humans
  • Low-Level Light Therapy / instrumentation
  • Low-Level Light Therapy / methods*
  • Regeneration / radiation effects
  • Rejuvenation*
  • Skin Aging / pathology
  • Skin Aging / physiology
  • Skin Aging / radiation effects*
  • Time Factors