doi: 10.1038/nsmb1204.
Epub 2007 Feb 18.
Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase
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- PMID: 17310254
- DOI: 10.1038/nsmb1204
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Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase
Nat Struct Mol Biol.
2007 Mar.
Erratum in
- Nat Struct Mol Biol. 2007 Apr;14(4):351
Abstract
Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5' regions of transcribed genes. Here we identify a novel budding yeast JmjC domain-containing H3-K4 demethylase, Jhd2p, that antagonizes the trimethyl modification state and contributes to regulation of telomeric silencing.
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