doi: 10.1038/nsmb1200.
Epub 2007 Feb 18.
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
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- PMID: 17310255
- DOI: 10.1038/nsmb1200
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Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
Nat Struct Mol Biol.
2007 Mar.
Abstract
Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using a conditional mutant of the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover of H3-K4me3 and H3-K4me2 in vivo and show this process requires Yjr119Cp, of the JARID1 family of JmjC proteins. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.
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