IL-15 an immunoregulatory and anti-cancer cytokine. Recent advances

J Exp Clin Cancer Res. 2006 Dec;25(4):529-36.


Interleukins are mediators of inflammation, immunity and cancer. IL-15 is a cytokine produced by several leukocytes including phagocytes in response to infections and other signals that trigger innate immunity. IL-15 has many homologies to interleukin-2 (IL-2) and like IL-2, stimulates NK cells. This cytokine acts also on memory CD8+ T-cell. IL-15, therefore acts, probably through selective inhibition of tumor promoting molecules, as a new compound for the adjuvant treatment of solid tumors. In this review we propose a newly revised mechanism of interleukin 15 in inflammation and cancer.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • B-Lymphocytes / immunology
  • Cytokines
  • Disease Progression
  • Hematologic Neoplasms / immunology
  • Hematologic Neoplasms / physiopathology
  • Humans
  • Interleukin-15 / therapeutic use*
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Lymphocyte Activation / drug effects
  • Mast Cells / immunology
  • T-Lymphocytes / immunology


  • Antineoplastic Agents
  • Cytokines
  • Interleukin-15