Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling

Nat Rev Neurosci. 2007 Mar;8(3):182-93. doi: 10.1038/nrn2093.


In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca(2+) sensor that has several defined roles in neuronal Ca(2+) signalling, but members of the neuronal calcium sensor protein family have also begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca(2+) signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / cytology
  • Calcium / metabolism*
  • Calcium Signaling / physiology*
  • Humans
  • Models, Molecular
  • Models, Neurological
  • Neuronal Calcium-Sensor Proteins / physiology*
  • Neurons / physiology*


  • Neuronal Calcium-Sensor Proteins
  • Calcium