Neuronal polarity: from extracellular signals to intracellular mechanisms

Nat Rev Neurosci. 2007 Mar;8(3):194-205. doi: 10.1038/nrn2056.


After they are born and differentiate, neurons break their previous symmetry, dramatically change their shape, and establish two structurally and functionally distinct compartments - axons and dendrites - within one cell. How do neurons develop their morphologically and molecularly distinct compartments? Recent studies have implicated several signalling pathways evoked by extracellular signals as having essential roles in a number of aspects of neuronal polarization.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Polarity / physiology*
  • Models, Biological
  • Neurons / physiology*
  • Protein Transport / physiology
  • Signal Transduction / physiology*