Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation

Lasers Surg Med. 2007 Feb;39(2):164-8. doi: 10.1002/lsm.20455.


Background and objective: Light-emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation-induced dermatitis in breast cancer.

Materials and methods: Patients (n=19) were treated with LED photomodulation (Gentlewaves, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity-modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age-matched controls (n=28) received IMRT without LED photomodulation.

Results: In LED-treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED-treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment.

Conclusion: LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy.

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / radiotherapy*
  • Female
  • Fibroblasts / radiation effects
  • Humans
  • Middle Aged
  • Phototherapy*
  • Prospective Studies
  • Radiodermatitis / prevention & control*
  • Radiotherapy, Intensity-Modulated / adverse effects