Adiponectin independently predicts metabolic syndrome in overweight Latino youth

J Clin Endocrinol Metab. 2007 May;92(5):1809-13. doi: 10.1210/jc.2006-2294. Epub 2007 Feb 20.

Abstract

Context: Adiponectin may be important in the pathogenesis of insulin resistance and the metabolic syndrome in youth.

Objective: The objective of the study was to determine the unique effect of adiponectin on the metabolic syndrome in overweight Latino youth.

Participants: Participants included 175 overweight children (aged 11.1 +/- 1.7 yr, body mass index percentile 97.3 +/- 2.9) with a family history of type 2 diabetes.

Methods: Metabolic syndrome was defined according to a pediatric adaptation of the Adult Treatment Panel III report and included dyslipidemia, abdominal obesity, elevated blood pressure, and prediabetes (impaired fasting glucose or impaired glucose tolerance from a 2-h oral glucose tolerance test). Body composition was estimated via dual-energy x-ray absorptiometry, insulin sensitivity was quantified by the frequently sampled iv glucose tolerance test, visceral fat was measured using magnetic resonance imaging, and adiponectin was determined in fasting serum.

Results: In simple linear regression, adiponectin was significantly and inversely related to systolic blood pressure (P < 0.05), waist circumference (P < 0.001), triglycerides (P < 0.001), and 2-h glucose levels (P < 0.05) and positively related to high-density lipoprotein-cholesterol (P < 0.001). In multiple linear regression, adiponectin was significantly related to triglycerides (P < 0.01) and high-density lipoprotein-cholesterol (P < 0.01) independent of age, gender, Tanner stage, body composition, and insulin sensitivity. Analyses of covariance established that adiponectin levels were approximately 25% higher in healthy overweight youth, compared with those with the metabolic syndrome (12.5 +/- 3.5 vs. 9.4 +/- 2.8 microg/ml; P < 0.05). In multiple logistic regression, adiponectin was a significant independent predictor of the metabolic syndrome, even after adjustment for confounders including insulin sensitivity and visceral fat.

Conclusions: Hypoadiponectinemia is an independent biomarker of the metabolic syndrome, and thus, adiponectin may play a role in the pathophysiology of the disorder in overweight youth.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Absorptiometry, Photon
  • Adiponectin / blood*
  • Adiposity / physiology
  • Adolescent
  • Biomarkers
  • Blood Pressure / physiology
  • Body Composition / physiology
  • Child
  • Female
  • Glucose Tolerance Test
  • Hispanic Americans
  • Humans
  • Insulin Resistance / physiology
  • Lipids / blood
  • Magnetic Resonance Imaging
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diagnosis*
  • Obesity / blood*
  • Phenotype
  • Predictive Value of Tests
  • Sex Characteristics

Substances

  • Adiponectin
  • Biomarkers
  • Lipids