Chromatin as an essential part of the transcriptional mechanism

Nature. 1992 Jan 16;355(6357):219-24. doi: 10.1038/355219a0.


The increasingly detailed biochemical definition of the protein complexes that regulate gene transcription has led to the re-emergence of questions about the role of histones. Much recent evidence suggests that transcriptional activation requires that transcription factors successfully compete with histones for binding to promoters, and that there may be more than one mechanism by which this is achieved.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / physiology*
  • Chromatin / ultrastructure
  • Histones / genetics
  • Histones / physiology
  • Mutation
  • Nucleosomes / physiology
  • Saccharomyces cerevisiae / genetics
  • Transcription Factors
  • Transcription, Genetic*


  • Chromatin
  • Histones
  • Nucleosomes
  • Transcription Factors