Tp53 expressing squamous cell carcinoma of the tonsil in a captive polar wolf (Canis lupus arctos)

J Zoo Wildl Med. 2005 Sep;36(3):538-42. doi: 10.1638/04-019.1.


The gross and histopathologic findings for a primary tonsillar squamous cell carcinoma in a captive 11-yr-old male polar wolf (Canis lupus arctos) are described. The carcinoma had metastasized to regional lymph nodes of the pharynx, the precardial mediastinum, and the lungs. Tumor suppressor protein TP53 was detected by immunohistochemistry in the nuclei of poorly differentiated, cytokeratin-positive cells of the primary neoplasm and the metastases. Canine oral papillomavirus DNA was not detectable by polymerase chain reaction (PCR).

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / veterinary*
  • Fatal Outcome
  • Lymphatic Metastasis*
  • Male
  • Palatine Tonsil / pathology
  • Tonsillar Neoplasms / metabolism
  • Tonsillar Neoplasms / pathology
  • Tonsillar Neoplasms / veterinary*
  • Tumor Suppressor Protein p53 / metabolism*
  • Wolves*


  • Tumor Suppressor Protein p53