Abstract
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in cancer. Three new crystal structures of PP2A show how it interacts with inhibitory toxins and with one of its regulatory subunits. The structures also explain how specific site mutations may lead to cancer and suggest a novel role for PP2A methylation in the formation of PP2A holoenzymes.
MeSH terms
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Amino Acid Substitution
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Crystallography, X-Ray
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Holoenzymes
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Humans
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Methylation
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Neoplasms / etiology
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Neoplasms / genetics
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Noxae / pharmacology
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Phosphoprotein Phosphatases / antagonists & inhibitors
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Phosphoprotein Phosphatases / chemistry*
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Phosphoprotein Phosphatases / genetics
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Protein Conformation
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Protein Phosphatase 2
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Protein Subunits
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Signal Transduction
Substances
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Holoenzymes
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Noxae
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Protein Subunits
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Phosphoprotein Phosphatases
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Protein Phosphatase 2