A new approach to label sentinel nodes in endometrial cancer

Gynecol Oncol. 2007 May;105(2):457-61. doi: 10.1016/j.ygyno.2007.01.021. Epub 2007 Feb 20.

Abstract

Purpose: The objective of the study was to determine the feasibility of a new method of labeling sentinel lymph nodes in patients with endometrial cancer using blue dye.

Patients and methods: 4 ml of blue dye was subserously administered in 25 patients with endometrial cancer at eight sites. After 8 min, sentinel lymph nodes were harvested.

Results: Detection rate was 92.0%, sensitivity was 62.5%, and negative predictive value was 92.5%. In two patients there was no detection of sentinel nodes and in addition in two patients only sentinel nodes were harvested due to minimal disease. No side effects occurred.

Conclusions: This new and simple approach yielded a high pelvic detection rate. This new approach reveals a way to label sentinel nodes in endometrial cancer. Combining a different labeling agent with the proposed new method might overcome the lack of para-aortic sentinel detection.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Endometrial Neoplasms / pathology*
  • Endometrial Neoplasms / surgery
  • Female
  • Humans
  • Lymph Nodes / pathology*
  • Lymph Nodes / surgery
  • Lymphatic Metastasis
  • Middle Aged
  • Rosaniline Dyes
  • Sensitivity and Specificity
  • Sentinel Lymph Node Biopsy / methods*

Substances

  • Rosaniline Dyes
  • sulfan blue