Rab cascades and tethering factors in the endomembrane system

FEBS Lett. 2007 May 22;581(11):2125-30. doi: 10.1016/j.febslet.2007.01.090. Epub 2007 Feb 12.


Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Endocytosis / physiology
  • Exocytosis / physiology
  • Guanine Nucleotide Exchange Factors / metabolism
  • Humans
  • Intracellular Membranes / metabolism*
  • Protein Transport / physiology
  • rab GTP-Binding Proteins / metabolism*


  • Guanine Nucleotide Exchange Factors
  • rab GTP-Binding Proteins