Making the connections--the crucial role of metabolite transporters at the interface between chloroplast and cytosol

FEBS Lett. 2007 May 25;581(12):2215-22. doi: 10.1016/j.febslet.2007.02.010. Epub 2007 Feb 15.


Eukaryotic cells are most fascinating because of their high degree of compartmentation. This is particularly true for plant cells, due to the presence of chloroplasts, photosynthetic organelles of endosymbiotic origin that can be traced back to a single cyanobacterial ancestor. Plastids are major hubs in the metabolic network of plant cells, their metabolism being heavily intertwined with that of the cytosol and of other organelles. Solute transport across the plastid envelope by metabolite transporters is key to integrating plastid metabolism with that of other cellular compartments. Here, we review the advances in understanding metabolite transport across the plastid envelope membrane.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adenine Nucleotide Translocator 1 / genetics
  • Adenine Nucleotide Translocator 1 / metabolism
  • Anion Transport Proteins / genetics
  • Anion Transport Proteins / metabolism
  • Arabidopsis Proteins / genetics
  • Arabidopsis Proteins / metabolism
  • Biological Transport, Active
  • Chloroplasts / metabolism*
  • Cytosol / metabolism
  • Endoplasmic Reticulum / metabolism
  • Folic Acid / metabolism
  • Genomics
  • Lipid Metabolism
  • Models, Biological
  • Phylogeny
  • Plants / genetics
  • Plants / metabolism*
  • Plastids / metabolism
  • S-Adenosylmethionine / metabolism
  • Systems Biology


  • Adenine Nucleotide Translocator 1
  • Anion Transport Proteins
  • Arabidopsis Proteins
  • SAMT1 protein, Arabidopsis
  • S-Adenosylmethionine
  • Folic Acid