INO80 subfamily of chromatin remodeling complexes

Mutat Res. 2007 May 1;618(1-2):18-29. doi: 10.1016/j.mrfmmm.2006.10.006. Epub 2007 Jan 21.

Abstract

ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. Recently characterized INO80 and SWR1 complexes belong to a subfamily of these chromatin remodelers and are characterized by a split ATPase domain in the core ATPase subunit and the presence of Rvb proteins. INO80 and SWR1 complexes are evolutionarily conserved from yeast to human and have been implicated in transcription regulation, as well as DNA repair. The individual components, assembly patterns, and molecular mechanisms of the INO80 class of chromatin remodeling complexes are discussed in this review.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenosine Triphosphatases / chemistry
  • Adenosine Triphosphatases / metabolism
  • Adenosine Triphosphate / chemistry
  • Animals
  • Chromatin / metabolism*
  • Chromatin Assembly and Disassembly*
  • DNA / chemistry
  • Evolution, Molecular
  • Humans
  • Protein Conformation
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / chemistry*

Substances

  • Chromatin
  • INO80 complex, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • Adenosine Triphosphate
  • DNA
  • Adenosine Triphosphatases
  • Swr1 protein, S cerevisiae