Crossing paths with Notch in the hyper-network

Curr Opin Cell Biol. 2007 Apr;19(2):166-75. doi: 10.1016/ Epub 2007 Feb 20.


The development of complex and diverse metazoan morphologies is coordinated by a surprisingly small number of evolutionarily conserved signaling mechanisms. These signals can act in parallel but often appear to function as an integrated hyper-network. The nodes defining this complex molecular circuitry are poorly understood, but the biological significance of pathway cross-talk is profound. The importance of such large-scale signal integration is exemplified by Notch and its ability to cross-talk with all the major pathways to influence cell differentiation, proliferation, survival and migration. The Notch pathway is, thus, a useful paradigm to illustrate the complexity of pathway cross-talk: its pervasiveness, context dependency, and importance in development and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Movement
  • Cell Proliferation
  • Humans
  • Models, Biological
  • Morphogenesis
  • Neoplasms / metabolism
  • Receptor Cross-Talk / physiology*
  • Receptors, Cell Surface
  • Receptors, Notch / metabolism*
  • Signal Transduction*
  • Stem Cells / metabolism


  • Receptors, Cell Surface
  • Receptors, Notch