Exercise-induced Hypertension, Endothelial Dysfunction, and Coronary Artery Disease in a Marathon Runner

Am J Cardiol. 2007 Mar 1;99(5):743-4. doi: 10.1016/j.amjcard.2006.09.127. Epub 2007 Jan 11.


Aerobic activity performed on a regular basis is 1 of several lifestyle recommendations endorsed to reduce risk of coronary disease. However, 1 potential concern of arduous aerobic activity is exercise-induced hypertension. This is the first case to our knowledge, of accelerated coronary calcification in an otherwise asymptomatic middle-aged male marathon runner devoid of traditional cardiovascular risk factors. As a consequence of exercise-induced hypertension and associated oxidative stress, improvement of endothelial dysfunction occurred after antioxidant supplementation. In conclusion, vigorous aerobic activity in susceptible individuals may promote oxidative stress and coronary atherosclerosis.

Publication types

  • Case Reports

MeSH terms

  • Coronary Artery Disease / etiology*
  • Coronary Artery Disease / physiopathology
  • Coronary Artery Disease / prevention & control
  • Endothelium, Vascular / physiopathology*
  • Humans
  • Hypertension / etiology*
  • Hypertension / physiopathology
  • Hypertension / prevention & control
  • Male
  • Middle Aged
  • Running / physiology*