Symmetry of optical coherence tomography retinal measurements in young children

Am J Ophthalmol. 2007 Mar;143(3):518-20. doi: 10.1016/j.ajo.2006.09.050. Epub 2006 Oct 19.


Purpose: To examine symmetry of macular, peripapillary nerve fiber layer (NFL), and optic disk measurements in healthy children.

Design: Cross-sectional study.

Methods: We examined a population-based sample of six-year-old children (n = 1,765) in the Sydney Childhood Eye Study. Optical coherence tomography (OCT) scan data for right and left eyes were compared.

Results: High interocular correlations (>0.8) were found for foveal minimum thickness and cup-to-disk ratios. Average NFL thickness was moderately correlated (0.7). Other macular, NFL, and optic disk parameters showed negligible or small mean interocular differences. In 95% of children, interocular difference in macular thickness was <22 microm for foveal minimum and <40 microm for other areas, and 16 to 17 microm for average NFL thickness. Cup-to-disk ratio was highly symmetric, varying by <0.25 in 95% of children.

Conclusions: Interocular asymmetry of retinal/optic disk parameters should be interpreted in the context of other clinical measures because of the potential for large degrees of asymmetry among individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthropometry
  • Biometry
  • Child
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Nerve Fibers*
  • Optic Disk / anatomy & histology*
  • Optic Nerve / anatomy & histology*
  • Retina / anatomy & histology*
  • Tomography, Optical Coherence*