Dose selection in stereotactic radiosurgery

Prog Neurol Surg. 2007;20:28-42. doi: 10.1159/000100093.


Selecting optimal doses for radiosurgery requires a thorough consideration of existing dose-response data for radiation injury of brain and surrounding structures and of the doseresponse for the desired endpoint (tumor control, obliteration of a vascular malformation, relief of trigeminal neuralgia, etc.). This paper reviews the radiobiological and physics principles that should be considered in dose selection as well as information from retrospective and prospective clinical investigations of radiosurgery.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / secondary
  • Brain Neoplasms / surgery*
  • Glioblastoma / surgery
  • Humans
  • Radiation Injuries / prevention & control
  • Radiosurgery / adverse effects
  • Radiosurgery / methods*
  • Radiotherapy Dosage*
  • Risk Assessment
  • Treatment Failure