The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

Nat Rev Cancer. 2007 Mar;7(3):182-91. doi: 10.1038/nrc2070.

Abstract

Intense research over the past four years has led to the discovery and characterization of a novel signalling network, known as the Salvador-Warts-Hippo (SWH) pathway, involved in tissue growth control in Drosophila melanogaster. At present, eleven proteins have been implicated as members of this pathway, and several downstream effector genes have been characterized. The importance of this pathway is emphasized by its evolutionary conservation, and by increasing evidence that its deregulation occurs in human tumours. Here, we review the main findings from Drosophila and the implications that these have for tumorigenesis in mammals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism
  • Drosophila Proteins / metabolism
  • Drosophila Proteins / physiology*
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Protein Kinases / physiology
  • Protein-Serine-Threonine Kinases / physiology
  • Signal Transduction / physiology*

Substances

  • Cell Cycle Proteins
  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • sav protein, Drosophila
  • Protein Kinases
  • wts protein, Drosophila
  • Protein-Serine-Threonine Kinases
  • hpo protein, Drosophila