Matrix metalloproteinases and the regulation of tissue remodelling

Nat Rev Mol Cell Biol. 2007 Mar;8(3):221-33. doi: 10.1038/nrm2125.


Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian metamorphosis, yet they have attracted more attention because of their roles in disease. Despite intensive scrutiny in vitro, in cell culture and in animal models, the normal physiological roles of these extracellular proteases have been elusive. Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological*
  • Animals
  • Blood Vessels / physiology*
  • Bone Remodeling
  • Bone and Bones / embryology
  • Bone and Bones / physiology
  • Embryonic Development
  • Humans
  • Immunity, Innate
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Mammary Glands, Animal / embryology
  • Mammary Glands, Animal / growth & development
  • Mammary Glands, Animal / physiology
  • Matrix Metalloproteinases / genetics
  • Matrix Metalloproteinases / physiology*
  • Mutation
  • Wound Healing / physiology


  • Matrix Metalloproteinases