Emerging roles of nuclear protein phosphatases

Nat Rev Mol Cell Biol. 2007 Mar;8(3):234-44. doi: 10.1038/nrm2126.


The phosphorylation state of any protein represents a balance of the actions of specific protein kinases and protein phosphatases. Many protein phosphatases are highly enriched in, or exclusive to, the nuclear compartment, where they dephosphorylate key substrates to regulate various nuclear processes. In this review we will discuss recent findings that define the role of nuclear protein phosphatases in controlling transforming growth factor-beta (TGFbeta) and bone-morphogenetic protein (BMP) signalling, the DNA-damage response, RNA processing, cell-cycle progression and gene transcription.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Morphogenetic Proteins / metabolism
  • Cell Cycle
  • Cell Nucleus / enzymology*
  • Cell Nucleus / metabolism
  • DNA Damage
  • Humans
  • Phosphoprotein Phosphatases / metabolism*
  • Protein Kinases / metabolism
  • RNA Processing, Post-Transcriptional
  • Signal Transduction
  • Transcription, Genetic
  • Transforming Growth Factor beta / metabolism


  • Bone Morphogenetic Proteins
  • Transforming Growth Factor beta
  • Protein Kinases
  • Phosphoprotein Phosphatases