DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans

Biochem Genet. 2007 Apr;45(3-4):155-63. doi: 10.1007/s10528-006-9047-9. Epub 2007 Feb 23.

Abstract

DNA-methyltransferase-3B (DNMT3b) plays an important role in the generation of aberrant methylation in carcinogenesis. DNMT3b SNP has been associated with susceptibility to lung, head, neck, and breast cancer, but its association with the development of colon cancer has not been reported. We investigated the relationship between the 39179GT polymorphism in the DNMT3b gene, which is involved in de novo methylation and is associated with the risk of adenocarcinoma of the colon in Koreans. The DNMT3b 39179GT genotypes were determined by a PCR-RFLP method in 248 adenocarcinomas of colon cancer patients and in 248 healthy controls matched as to age and sex. When stratified by sex and age, a significantly reduced risk of the combined GT and GG genotypes was observed in younger patients (<59, adjusted OR = 0.255, 95% CI = 0.133-0.489) and in male patients (adjusted OR = 0.383, 95% CI = 0.225-0.652). The DNMT3b 39179GT polymorphism may be a genetic determinant of adenocarcinoma of the colon, especially in younger Korean men.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics*
  • Asian Continental Ancestry Group / genetics*
  • Base Sequence
  • Case-Control Studies
  • Colonic Neoplasms / enzymology
  • Colonic Neoplasms / genetics*
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genotype
  • Guanine
  • Humans
  • Korea
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Odds Ratio
  • Polymorphism, Restriction Fragment Length
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • Thymine

Substances

  • Guanine
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA methyltransferase 3B
  • Thymine