Elevated rates of sister chromatid exchange at chromosome ends

PLoS Genet. 2007 Feb 23;3(2):e32. doi: 10.1371/journal.pgen.0030032.


Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Chromosomes, Human
  • Humans
  • In Situ Hybridization, Fluorescence
  • Models, Biological
  • Molecular Sequence Data
  • Sister Chromatid Exchange*
  • Telomere / genetics*
  • Tumor Cells, Cultured

Associated data

  • GENBANK/AC004908
  • GENBANK/AC104236
  • GENBANK/AL078621
  • GENBANK/AQ747375
  • GENBANK/AQ747941