Post-ischemic treatment of pentoxifylline reduces cortical not striatal infarct volume in transient model of focal cerebral ischemia in rat

Brain Res. 2007 May 4;1144:186-91. doi: 10.1016/j.brainres.2007.01.096. Epub 2007 Feb 1.

Abstract

Previous studies reported that pentoxifylline (PTX) have a neuroprotective effect in the brain trauma and the global cerebral ischemia in the experimental models. However, the effect of PTX in transient model of focal cerebral ischemia has not been investigated yet. Therefore, this study was designed to investigate the effect of post-ischemic treatment of PTX on ischemic injuries in focal cerebral ischemic. Male Wistar rats (n=32) were assigned to control or PTX- (60 mg/kg i.p.) treated groups. PTX at dose 60 mg/kg i.p. administered at the beginning, or 1, or 3 h after ischemia. Focal cerebral ischemia was induced by middle cerebral artery occlusion, followed by 24-h reperfusion. At the end of 24 h ischemia, neurological dysfunction score was tested and infarct volumes were determined using triphenyltetrazolium chloride staining. Administration of PTX (60 mg/kg) at the beginning of ischemia, or 1, or 3 h after ischemia significantly reduces cortical infarct volumes by 43%, 40% and 41%, respectively. However, PTX did not significantly affect striatal infarct volumes and neurological dysfunction. The findings of the present study indicate that administration of PTX at least 3 h post-transient focal stroke reduces cortical brain ischemic damage in the rat model of transient focal cerebral ischemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Brain Infarction / etiology
  • Brain Infarction / pathology*
  • Brain Infarction / prevention & control*
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / pathology
  • Corpus Striatum / drug effects*
  • Corpus Striatum / pathology
  • Disease Models, Animal
  • Ischemic Attack, Transient / complications
  • Male
  • Pentoxifylline / therapeutic use*
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Rats
  • Rats, Wistar
  • Severity of Illness Index
  • Time Factors

Substances

  • Platelet Aggregation Inhibitors
  • Pentoxifylline