Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 128 (4), 693-705

Chromatin Modifications and Their Function

Affiliations
Review

Chromatin Modifications and Their Function

Tony Kouzarides. Cell.

Abstract

The surface of nucleosomes is studded with a multiplicity of modifications. At least eight different classes have been characterized to date and many different sites have been identified for each class. Operationally, modifications function either by disrupting chromatin contacts or by affecting the recruitment of nonhistone proteins to chromatin. Their presence on histones can dictate the higher-order chromatin structure in which DNA is packaged and can orchestrate the ordered recruitment of enzyme complexes to manipulate DNA. In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.

Similar articles

  • Histone Modification: Cause or Cog?
    S Henikoff et al. Trends Genet 27 (10), 389-96. PMID 21764166.
    Histone modifications are key components of chromatin packaging but whether they constitute a 'code' has been contested. We believe that the central issue is causality: a …
  • Histone Modifications and Chromatin Remodeling During Bacterial Infections
    MA Hamon et al. Cell Host Microbe 4 (2), 100-9. PMID 18692770. - Review
    The link between bacteria and host chromatin remodeling is an emerging topic. The exciting recent discoveries on bacterial impact on host epigenetics, as discussed in thi …
  • Interplay Between Different Epigenetic Modifications and Mechanisms
    R Murr. Adv Genet 70, 101-41. PMID 20920747. - Review
    Cellular functions including transcription regulation, DNA repair, and DNA replication need to be tightly regulated. DNA sequence can contribute to the regulation of thes …
  • Chromatin Response to DNA Double-Strand Break Damage
    Y Bao. Epigenomics 3 (3), 307-21. PMID 22122340. - Review
    Manipulation of chromatin, in which genomic DNA is packaged, is a fundamental requirement for all DNA-based metabolic processes in eukayotic cells. Histone variant incorp …
  • Chromatin Proteomics and Epigenetic Regulatory Circuits
    C Bönisch et al. Expert Rev Proteomics 5 (1), 105-19. PMID 18282127. - Review
    Many phenotypic changes of eukaryotic cells due to changes in gene expression depend on alterations in chromatin structure. Processes involved in the alteration of chroma …
See all similar articles

Cited by 3,587 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback