Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Nahyun Kim; Jin Chul Shin; Woncheol Kim; Bang Yeon Hwang; Beom Seok Kim; Young-Soo Hong; Dongho Lee

doi:10.1038/ja.2006.105

Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

J Antibiot (Tokyo). 2006 Dec;59(12):797-800. doi: 10.1038/ja.2006.105.

Authors

Nahyun Kim¹, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young-Soo Hong, Dongho Lee

Affiliation

¹ Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea.

PMID: 17323647
DOI: 10.1038/ja.2006.105

Abstract

Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 microg/ml, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Humans
Salicylates / chemistry
Salicylates / isolation & purification*
Salicylates / pharmacology
Streptomyces / metabolism*

Substances

Antineoplastic Agents
Salicylates
salaceyin A
salaceyin B