Sensing of glucose in the gastrointestinal tract

Auton Neurosci. 2007 Apr 30;133(1):86-90. doi: 10.1016/j.autneu.2007.01.006. Epub 2007 Feb 26.


In general, nutrient sensing mechanisms in the intestine are not well understood. Potential sensors include the terminals of extrinsic afferent nerves, enteric nerves, endocrine cells and other epithelial cells including enterocytes and immune cells. This short review will concentrate on the neural pathways that are activated by the presence of glucose in the intestinal lumen and the role of a specialized endocrine cell, the enterochromaffin cell in glucose-sensing and the subsequent activation of extrinsic neural pathways.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Gastrointestinal Tract / metabolism*
  • Glucose / metabolism*
  • Neural Pathways / physiology*


  • Glucose