This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2007 Mar;35(3):501-2.

doi: 10.1124/dmd.106.013359.

Misuse of the well-stirred model of hepatic drug clearance

Jiansong Yang, Masoud Jamei, Karen R Yeo, Amin Rostami-Hodjegan, Geoffrey T Tucker

PMID: 17325025
DOI: 10.1124/dmd.106.013359

Misuse of the well-stirred model of hepatic drug clearance

Jiansong Yang et al. Drug Metab Dispos. 2007 Mar.

. 2007 Mar;35(3):501-2.

doi: 10.1124/dmd.106.013359.

Authors

Jiansong Yang, Masoud Jamei, Karen R Yeo, Amin Rostami-Hodjegan, Geoffrey T Tucker

PMID: 17325025
DOI: 10.1124/dmd.106.013359

No abstract available

PubMed Disclaimer

Similar articles

Hepatic circulation and drug disposition in cirrhosis.
Shand DG. Shand DG. Gastroenterology. 1979 Jul;77(1):185-6. Gastroenterology. 1979. PMID: 447017 No abstract available.
Clearance and biologic half-life as indices of intrinsic hepatic metabolism.
Perrier D, Gibaldi M. Perrier D, et al. J Pharmacol Exp Ther. 1974 Oct;191(1):17-24. J Pharmacol Exp Ther. 1974. PMID: 4423599 No abstract available.
Exact mathematical equivalence of the venous equilibration ("well-stirred") model, the sinusoidal perfusion ("parallel-tube") model, and a specific two-compartment open model.
Wagner JG, Szpunar GJ, Ferry JJ. Wagner JG, et al. Drug Metab Dispos. 1984 Jul-Aug;12(4):385-8. Drug Metab Dispos. 1984. PMID: 6148202 No abstract available.
Drug administration in hepatic disease.
Williams RL. Williams RL. N Engl J Med. 1983 Dec 29;309(26):1616-22. doi: 10.1056/NEJM198312293092605. N Engl J Med. 1983. PMID: 6358891 Review. No abstract available.
Clearance approaches in pharmacology.
Wilkinson GR. Wilkinson GR. Pharmacol Rev. 1987 Mar;39(1):1-47. Pharmacol Rev. 1987. PMID: 3554275 Review. No abstract available.

See all similar articles

Cited by

Precision Dosing Management with Intelligent Computing in Digital Health.
Lu H, Rosenbaum S, Lu W. Lu H, et al. Proc Int Conf Intell Netw Collab Syst. 2020 Aug-Sep;1263:269-280. doi: 10.1007/978-3-030-57796-4_26. Epub 2020 Aug 21. Proc Int Conf Intell Netw Collab Syst. 2020. PMID: 37915763 Free PMC article.
Dolutegravir pharmacokinetics in Ugandan patients with TB and HIV receiving standard- versus high-dose rifampicin.
Kengo A, Nabisere R, Gausi K, Musaazi J, Buzibye A, Omali D, Aarnoutse R, Lamorde M, Dooley KE, Sloan DJ, Denti P, Sekaggya-Wiltshire C. Kengo A, et al. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0043023. doi: 10.1128/aac.00430-23. Epub 2023 Oct 18. Antimicrob Agents Chemother. 2023. PMID: 37850738 Free PMC article. Clinical Trial.
Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2.
Lignet F, Friese-Hamim M, Jaehrling F, El Bawab S, Rohdich F. Lignet F, et al. Pharm Res. 2023 Dec;40(12):3011-3023. doi: 10.1007/s11095-023-03611-z. Epub 2023 Oct 5. Pharm Res. 2023. PMID: 37798538 Free PMC article.
Use of Clearance Concepts to Simulate Impact of Interleukin-6 on Drug Elimination Governed by Cytochromes P450 3A4 and Glomerular Filtration Rate.
Chen X, Yu G, Li GF. Chen X, et al. Eur J Drug Metab Pharmacokinet. 2023 Nov;48(6):619-621. doi: 10.1007/s13318-023-00859-z. Epub 2023 Oct 4. Eur J Drug Metab Pharmacokinet. 2023. PMID: 37792131 No abstract available.
Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease.
El-Khateeb E, Chinnadurai R, Al Qassabi J, Scotcher D, Darwich AS, Kalra PA, Rostami-Hodjegan A. El-Khateeb E, et al. Ther Drug Monit. 2023 Dec 1;45(6):743-753. doi: 10.1097/FTD.0000000000001108. Epub 2023 Jun 13. Ther Drug Monit. 2023. PMID: 37315152 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- HighWire
Other Literature Sources
- The Lens - Patent Citations