Syringoma: a clinicopathologic and immunohistologic study and results of treatment

Yonsei Med J. 2007 Feb 28;48(1):35-40. doi: 10.3349/ymj.2007.48.1.35.


The purpose of our study was to describe clinical and histopathological features of sixty one patients with histological diagnosis of syringoma over four year period in our dermatology clinic in Korea. Female:male ratio was 6.6:1 with onset of age during 2nd and 3rd decades in more than half of the patients in our study. The most frequently involved site was eyelids (43 cases, 70.5%) and the most common color of lesion was skin-color (30 cases, 49.2%). In 34 cases, characteristic tad-pole appearances (55.7%) were observed. Basal hyperpigmentation was observed more frequently in brown-colored lesion (p=0.005). Fibrosis was observed more frequently in erythematous lesion (p=0.033). Keratin cyst was observed less frequently in genital involved group (p=0.006). We also performed immunohistochemical stain for the presence of progesterone receptor (PR) and estrogen receptor (ER) in fifty six cases with negative results.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Eyelids / pathology
  • Female
  • Fibrosis / pathology
  • Humans
  • Hyperpigmentation / pathology
  • Immunohistochemistry
  • Keratins / analysis
  • Korea
  • Male
  • Middle Aged
  • Receptors, Estrogen / analysis
  • Receptors, Progesterone / analysis
  • Sweat Gland Neoplasms / metabolism
  • Sweat Gland Neoplasms / pathology*
  • Sweat Gland Neoplasms / therapy
  • Syringoma / metabolism
  • Syringoma / pathology*
  • Syringoma / therapy
  • Treatment Outcome


  • Receptors, Estrogen
  • Receptors, Progesterone
  • Keratins