Collagen fragments modulate innate immunity

Exp Biol Med (Maywood). 2007 Mar;232(3):406-11.


Activation of the innate immune response in diseases such as rheumatoid arthritis and atherosclerosis leads to the production of proinflammatory cytokines that can promote collagenolysis. While a number of studies suggest that inflammation plays a major role in initiating collagen degradation, the effect of collagen and collagen-degradation fragments on the inflammatory response is not well understood. We now demonstrate that different collagen fragments can either augment or suppress IL-1beta production from human peripheral-blood monocytes. These data have wide-ranging implications for how amino acid variation in collagen affects disease and suggest that collagen degradation leads to the production of peptides that can modulate inflammation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Collagen / chemistry
  • Collagen / pharmacology*
  • Drug Synergism
  • Humans
  • Immunity, Innate / drug effects*
  • Interleukin-1beta / metabolism
  • Lipopolysaccharides / pharmacology
  • Molecular Sequence Data
  • Monocytes / drug effects
  • Monocytes / metabolism
  • Peptide Fragments / pharmacology*


  • Interleukin-1beta
  • Lipopolysaccharides
  • Peptide Fragments
  • Collagen