Abstract
The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of (22E,24R)-ergosta-7,22-diene-3beta,5alpha,6beta-triol (1), ergosterol-3-O-beta-D-glucopyranoside (2), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (3), hypsiziprenol A9 (4), hypsiziprenol AA8 (5), hypsiziprenol AA9 (6) and hypsiziprenol BA10 (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / chemistry*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Biological Assay / methods
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Cell Survival / drug effects
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Chemical Fractionation / methods
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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HT29 Cells
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Mycotoxins / chemistry
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Mycotoxins / isolation & purification*
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Mycotoxins / pharmacology
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Technology, Pharmaceutical* / methods
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors
Substances
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Antineoplastic Agents
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Enzyme Inhibitors
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Mycotoxins
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors