Cytotoxic constituents isolated from the fruit bodies of Hypsizigus marmoreus

Arch Pharm Res. 2007 Jan;30(1):28-33. doi: 10.1007/BF02977775.

Abstract

The bioactivity-guided fractionation of chloroform extracts of the fruit bodies of Hypsizigus marmoreus led to our isolation of (22E,24R)-ergosta-7,22-diene-3beta,5alpha,6beta-triol (1), ergosterol-3-O-beta-D-glucopyranoside (2), 5alpha,8alpha-epidioxyergosta-6,22-dien-3beta-ol (3), hypsiziprenol A9 (4), hypsiziprenol AA8 (5), hypsiziprenol AA9 (6) and hypsiziprenol BA10 (7). Among these seven isolates, compound 2 was identified for the first time from this plant. All compounds (1-7) exhibited moderate cytotoxicity towards cultured human colon carcinoma (HT-29), human breast carcinoma (MCF-7) and human hepatoblastoma (HepG-2) cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Biological Assay / methods
  • Cell Survival / drug effects
  • Chemical Fractionation / methods
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • HT29 Cells
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Mycotoxins / chemistry
  • Mycotoxins / isolation & purification*
  • Mycotoxins / pharmacology
  • Technology, Pharmaceutical* / methods
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Mycotoxins
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors