Secondary metabolites from Andrographis paniculata

Chem Pharm Bull (Tokyo). 2007 Mar;55(3):455-8. doi: 10.1248/cpb.55.455.

Abstract

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside (1) and 5-hydroxy-7,8,2',5'-tetramethoxy-flavone-5-O-beta-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 microg/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Andrographis / chemistry*
  • Andrographis / metabolism*
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Carcinoma, Squamous Cell / drug therapy
  • Diterpenes / chemistry
  • Diterpenes / metabolism*
  • Diterpenes / pharmacology*
  • Humans
  • KB Cells
  • Molecular Structure

Substances

  • Antineoplastic Agents
  • Diterpenes