B-type natriuretic peptide predicts cardiac morbidity and mortality after major surgery

Br J Surg. 2007 Jul;94(7):903-9. doi: 10.1002/bjs.5690.

Abstract

Background: The objective of this study was to determine whether measurement of B-type natriuretic peptide (BNP) concentration before operation could be used to predict perioperative cardiac morbidity.

Methods: A prospective derivation study was performed in high-risk patients undergoing major non-cardiac surgery, with a subsequent validation study. A venous blood sample was taken the day before surgery for measurement of plasma BNP concentration. Screening for cardiac events (non-fatal myocardial infarction and cardiac death) was performed using clinical criteria, cardiac troponin I analysis and serial electrocardiography.

Results: Forty-one patients were recruited to the derivation cohort and 149 to the validation cohort. In the derivation cohort, the median (interquartile range) BNP concentration in the 11 patients who had a postoperative cardiac event was 210 (165-380) pg/ml, compared with 34.5 (14-70) pg/ml in those with no cardiac complications (P < 0.001). In the validation cohort, the median BNP concentration in the 15 patients who had a cardiac event was 351 (127-1034) pg/ml, compared with 30.5 (11-79.5) pg/ml in the remainder (P < 0.001). BNP concentration remained a significant outcome predictor in multivariable analysis (P < 0.001). Using receiver-operator curve analysis it was calculated that a BNP concentration of 108.5 pg/ml best predicted the likelihood of cardiac events, with a sensitivity and specificity of 87 per cent each.

Conclusion: Preoperative serum BNP concentration predicted postoperative cardiac events in patients undergoing major non-cardiac surgery independently of other risk factors.

Publication types

  • Validation Study

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Heart Diseases / blood
  • Heart Diseases / mortality*
  • Humans
  • Male
  • Natriuretic Peptide, Brain / metabolism*
  • Postoperative Complications / blood
  • Postoperative Complications / mortality*
  • Predictive Value of Tests
  • Preoperative Care
  • Prospective Studies
  • Troponin I / blood

Substances

  • Troponin I
  • Natriuretic Peptide, Brain