Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;39(4):540-3.
doi: 10.1038/ng1988. Epub 2007 Mar 4.

Mitochondrial Point Mutations Do Not Limit the Natural Lifespan of Mice

Affiliations

Mitochondrial Point Mutations Do Not Limit the Natural Lifespan of Mice

Marc Vermulst et al. Nat Genet. .

Abstract

Whether mitochondrial mutations cause mammalian aging, or are merely correlated with it, is an area of intense debate. Here, we use a new, highly sensitive assay to redefine the relationship between mitochondrial mutations and age. We measured the in vivo rate of change of the mitochondrial genome at a single-base pair level in mice, and we demonstrate that the mutation frequency in mouse mitochondria is more than ten times lower than previously reported. Although we observed an 11-fold increase in mitochondrial point mutations with age, we report that a mitochondrial mutator mouse was able to sustain a 500-fold higher mutation burden than normal mice, without any obvious features of rapidly accelerated aging. Thus, our results strongly indicate that mitochondrial mutations do not limit the lifespan of wild-type mice.

Comment in

Similar articles

See all similar articles

Cited by 159 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback