Variation of linker length in ratiometric fluorescent sensor proteins allows rational tuning of Zn(II) affinity in the picomolar to femtomolar range

J Am Chem Soc. 2007 Mar 28;129(12):3494-5. doi: 10.1021/ja069105d. Epub 2007 Mar 3.

Authors

Elisabeth M W M van Dongen¹, Toon H Evers, Linda M Dekkers, E W Meijer, Leo W J Klomp, Maarten Merkx

Affiliation

¹ Laboratory of Macromolecular and Organic Chemistry, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

PMID: 17335212
DOI: 10.1021/ja069105d

No abstract available

MeSH terms

Cross-Linking Reagents / chemistry*
Fluorescence Resonance Energy Transfer
Models, Molecular
Peptides / chemistry
Protein Structure, Tertiary
Proteins / chemistry*
Zinc / chemistry*

Substances

Cross-Linking Reagents
Peptides
Proteins
Zinc