Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells

FEBS Lett. 2007 Mar 20;581(6):1137-42. doi: 10.1016/j.febslet.2007.02.025. Epub 2007 Feb 20.

Abstract

Expression of CUB domain containing protein 1 (CDCP1) is upregulated in carcinoma cells. We quantitated CDCP1 gene expression in matched normal colon and tumour tissue and compared the level of expression to other genes upregulated in colorectal tumourigenesis. Furthermore, we show that the CDCP1 gene generates two transcripts which are co-expressed in normal and matched tumour tissue as well as in the majority of cell lines analysed. However, intracellular localisation studies revealed that only one of these transcripts encodes a protein that is localised to the cell surface.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / analysis*
  • Antigens, CD / genetics
  • Antigens, Neoplasm
  • Cell Adhesion Molecules / analysis*
  • Cell Adhesion Molecules / genetics
  • Cell Line, Tumor
  • Colorectal Neoplasms / metabolism
  • Colorectal Neoplasms / pathology*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Membrane Proteins
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / genetics
  • RNA, Messenger
  • RNA, Neoplasm
  • Up-Regulation / genetics

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • CDCP1 protein, human
  • Cell Adhesion Molecules
  • Membrane Proteins
  • Neoplasm Proteins
  • RNA, Messenger
  • RNA, Neoplasm