Regulating cytoskeleton-based vesicle motility

FEBS Lett. 2007 May 22;581(11):2112-8. doi: 10.1016/j.febslet.2007.01.094. Epub 2007 Feb 20.

Abstract

During vesicular transport, the assembly of the coat complexes and the selection of cargo proteins must be coordinated with the subsequent translocation of vesicles from the donor to an acceptor compartment. Here, we review recent progress toward uncovering the molecular mechanisms that connect transport vesicles to the protein machinery responsible for cytoskeleton-mediated motility. An emerging theme is that vesicle cargo proteins, either directly or through binding interactions with coat proteins, are able to influence cytoskeletal dynamics and motor protein function. Hence, a vesicle's cargo composition may help direct its intracellular motility and targeting.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Clathrin / metabolism
  • Cytoskeleton / metabolism*
  • Endocytosis / physiology
  • Golgi Apparatus / metabolism
  • Humans
  • Kinesin / chemistry
  • Kinesin / metabolism
  • Microtubules / metabolism
  • Molecular Motor Proteins / metabolism
  • Myosins / chemistry
  • Myosins / metabolism
  • Transport Vesicles / metabolism*

Substances

  • Actins
  • Clathrin
  • Molecular Motor Proteins
  • Myosins
  • Kinesin