High prevalence of serum autoantibodies against the amino terminal of alpha-enolase in Hashimoto's encephalopathy

J Neuroimmunol. 2007 Apr;185(1-2):195-200. doi: 10.1016/j.jneuroim.2007.01.018. Epub 2007 Mar 1.


Recently, we discovered autoantibodies against the amino (NH(2))-terminal of alpha-enolase (NAE) in patients with Hashimoto's encephalopathy (HE) (83.3%; 5/6) [Fujii, A., Yoneda, M., Ito, T., Yamamura, O., Satomi, S., Higa, H., Kimura, M., Suzuki, M., Yamashita, M., Yuasa, T., Suzuki, H., Kuriyama, M., 2005. Autoantibodies against the amino terminal of alpha-enolase are a useful diagnostic marker of Hashimoto's encephalopathy. J. Neuroimmunol. 162, 130-136]. We further investigated the anti-NAE autoantibodies in 25 patients who fit the diagnostic criteria for HE, based on the presence of anti-thyroid antibodies and responsiveness to immunotherapy. In this study, we demonstrated a high prevalence (68%, 17 of 25) and high specificity of anti-NAE autoantibodies in patients with HE, and clarified the clinical features of HE. This result demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoantibodies, are emphasized as useful serological diagnostic markers of HE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Autoantibodies / blood*
  • Blotting, Western
  • Brain Diseases / blood
  • Brain Diseases / etiology*
  • Brain Diseases / immunology*
  • Electrophoresis, Polyacrylamide Gel
  • Female
  • Hashimoto Disease / complications*
  • Humans
  • Male
  • Middle Aged
  • Phosphopyruvate Hydratase / chemistry
  • Phosphopyruvate Hydratase / immunology*
  • Prevalence


  • Autoantibodies
  • Phosphopyruvate Hydratase