T cells and B cells in lupus nephritis

Semin Nephrol. 2007 Jan;27(1):47-58. doi: 10.1016/j.semnephrol.2006.09.007.


T and B lymphocytes play diverse roles at multiple stages in the development and progression of lupus nephritis. Disruption of T- and B-cell regulatory functions by environmental and genetic influences permits pathogenic effectors to emerge in disease. New insights into the biology of these multifunctional cells offer novel targets for intervention in lupus nephritis and systemic autoimmunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoantibodies / immunology
  • B-Lymphocytes / immunology*
  • Cytokines / physiology
  • Humans
  • Immune Tolerance
  • Lupus Nephritis / etiology
  • Lupus Nephritis / immunology*
  • Lupus Nephritis / therapy
  • T-Lymphocytes / immunology*


  • Autoantibodies
  • Cytokines