Localisation of the gene for Norrie disease to between DXS7 and DXS426 on Xp

Hum Genet. 1992 Jan;88(3):349-50. doi: 10.1007/BF00197273.

Abstract

A highly informative microsatellite marker, DXS426, which maps proximal to DXS7 in the interval Xp11.4-Xp11.23, has been used to refine further the localisation of the gene for Norrie disease (NDP). The results from a multiply informative crossover localize the NDP gene proximal to DXS7. In conjunction with information from 2 NDP patients who have a deletion for DXS7 but not for DSX426, our data indicate that the NDP gene lies between DXS7 and DXS426 on proximal Xp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Blindness / genetics*
  • Chromosome Mapping
  • DNA / genetics
  • Genetic Linkage*
  • Heterozygote
  • Humans
  • Molecular Sequence Data
  • Pedigree
  • X Chromosome*

Substances

  • DNA