The path to insulin resistance: paved with ceramides?

Cell Metab. 2007 Mar;5(3):161-3. doi: 10.1016/j.cmet.2007.02.005.


Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor alpha, and glucocorticoids increase intracellular lipid metabolites and promote insulin resistance. In this issue, Holland et al. (2007) provide pharmacological and genetic evidence that ceramide plays a key role in the development of insulin resistance induced by these factors.

Publication types

  • Comment

MeSH terms

  • Animals
  • Ceramides / metabolism*
  • Humans
  • Insulin Resistance*
  • Lipid Metabolism
  • Mice
  • Obesity / metabolism


  • Ceramides