Abstract
Vascular calcification is clinically important in the development of cardiovascular disease. It has been suggested that apoptosis and chondro/osteogenic differentiation of vascular smooth muscle cells (VSMC) play important roles in the initiation and progression of vascular calcification. During the process of vascular calcification, growth arrest-specific gene 6 (Gas6) mediated-survival pathway is downregulated in VSMC, leading to apoptosis. Chondro/osteogenic differentiation regulated by transcription factors such as core binding factor alpha1 (Cbfa1) or msh homeo box homolog 2 (Msx2), promotes VSMC calcification. It is clear that vascular calcification is an active process regulated by various factors including Gas6, Cbfa1, or Msx2.
MeSH terms
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Animals
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Apoptosis / genetics
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Apoptosis / physiology
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Calcinosis / genetics*
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Cardiovascular Diseases / etiology
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Cell Differentiation / genetics*
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Cell Differentiation / physiology*
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Chondrocytes / cytology
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Core Binding Factor Alpha 1 Subunit / physiology*
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DNA-Binding Proteins / physiology*
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Homeodomain Proteins / physiology*
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Humans
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Intercellular Signaling Peptides and Proteins / physiology*
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Muscle, Smooth, Vascular / pathology*
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Myocytes, Smooth Muscle / cytology
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Osteocytes / cytology
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Signal Transduction / genetics
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Signal Transduction / physiology
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Transcription Factors / physiology*
Substances
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Core Binding Factor Alpha 1 Subunit
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DNA-Binding Proteins
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Homeodomain Proteins
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Intercellular Signaling Peptides and Proteins
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MSX2 protein
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Transcription Factors
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growth arrest-specific protein 6