Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis

Acta Derm Venereol. 2007;87(2):127-34. doi: 10.2340/00015555-0184.


The PSORS1 locus is the consistently replicated genetic risk factor for psoriasis. Clinical associations with the main marker allele of PSORS1, HLA-Cw6, have been addressed in a number of studies, but clinical associations have not been used as a way to distinguish the effects of the neighbouring candidate genes in PSORS1. Our results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. The clinical profiling of a small group of patients (n=34) who were HLA-Cw6- but CCHCR1*WWCC positive suggested that no great differences existed between them and HCR-Cw6- patients. HCR+ genotype (as well as Cw6+ genotype) correlated for the first time positively with female sex and, in contrast with previous studies, negatively with disease severity. Presence of psoriatic arthritis was more pronounced in HCR- psoriasis (as well as in Cw6- psoriasis). Clinical profiling may be a useful approach to distinguishing genetic effects of candidate genes even within a locus in sufficiently large cohorts.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Arthritis, Psoriatic / genetics*
  • Arthritis, Psoriatic / pathology
  • Child
  • Child, Preschool
  • Genetic Predisposition to Disease
  • HLA-C Antigens / genetics*
  • HLA-C Antigens / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Middle Aged
  • Psoriasis / genetics*
  • Psoriasis / immunology
  • Psoriasis / pathology
  • Sex Factors


  • CCHCR1 protein, human
  • HLA-C Antigens
  • HLA-C*06 antigen
  • Intracellular Signaling Peptides and Proteins