Abstract
We sought to investigate the link between substance abuse and increased striatal gray matter densities (GMD) in schizophrenia, using voxel-based morphometry (VBM). Increased striatal GMD were found in patients with schizophrenia and substance use disorder (n=12), but not schizophrenia only patients (n=11), compared to healthy volunteers (n=15).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antipsychotic Agents / pharmacology
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Antipsychotic Agents / therapeutic use
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Cell Count
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Corpus Striatum / drug effects
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Corpus Striatum / pathology*
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Diagnostic and Statistical Manual of Mental Disorders
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Female
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Haloperidol / pharmacology
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Haloperidol / therapeutic use
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Humans
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Magnetic Resonance Spectroscopy
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Male
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Receptors, Dopamine D2 / drug effects
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Schizophrenia* / drug therapy
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Schizophrenia* / epidemiology
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Schizophrenia* / pathology
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Severity of Illness Index
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Substance-Related Disorders / diagnosis
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Substance-Related Disorders / epidemiology*
Substances
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Antipsychotic Agents
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Receptors, Dopamine D2
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Haloperidol