Obesity and low-grade inflammation among young Finnish men with early-onset alopecia

Dermatology. 2007;214(2):125-9. doi: 10.1159/000098570.


Background: Previous investigations have revealed an association of androgenetic alopecia (AGA), especially in younger subjects with severe early-onset AGA, with ischemic heart disease.

Objective: To examine the possible association between early-onset alopecia and low-grade inflammation measured by high-sensitivity C-reactive protein (hs-CRP) that has been recommended for the assessment of the cardiovascular disease (CVD) risk.

Methods: The study population consisted of young men (n = 727, aged 25-34 years) participating in a national survey. The grade of alopecia was assessed by a trained nurse using the Norwood/Hamilton Classification Scale.

Results: Men with moderate to extensive alopecia (17%) had a higher body mass index and larger waist, upper arm, hip and waist circumference than those with little to no alopecia (p < 0.05), and statistically insignificant differences were seen in the waist-to-hip circumference ratio (WHR), diastolic blood pressure and hs-CRP. With increasing hs-CRP, the mean WHR increased, but only among men with moderate to extensive alopecia (p = 0.043).

Conclusion: Our findings show a relation between moderate to extensive alopecia and low-grade inflammation--a predictor of a future CVD--especially combined with central obesity, among men younger than 35 years.

MeSH terms

  • Adult
  • Alopecia / complications*
  • Alopecia / epidemiology
  • Blood Pressure / physiology
  • C-Reactive Protein / metabolism
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / physiopathology
  • Finland / epidemiology
  • Health Surveys
  • Humans
  • Inflammation / complications*
  • Inflammation / epidemiology
  • Male
  • Obesity / complications*
  • Obesity / epidemiology
  • Predictive Value of Tests
  • Prevalence
  • Risk Factors
  • Waist-Hip Ratio


  • C-Reactive Protein